HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Ethylthiophene-3-carboxylic acid → (5-Ethylthiophen-3-yl)(9-(3-(2-hydroxyethyl)benzyl)-2,2-dimethyl-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Ethylthiophene-3-carboxylic acid | HCID 3561548 | — |
| Reactant | 2-(3-((2,2-Dimethyl-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenyl)ethanol | HCID 57989091 | — |
| Product | (5-Ethylthiophen-3-yl)(9-(3-(2-hydroxyethyl)benzyl)-2,2-dimethyl-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)methanone | HCID 57988969 | — |
Reaction Steps
The subtitled compound was prepared using a similar method to that described in Example 271 step (f) using 2-(3-((2,2-dimethyl-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenyl)ethanol (0.2 g) (Example 271, step e) and 5-ethylthiophene-3-carboxylic acid. Yield 0.22 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08629271B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-0897fd7b3d094660bdd5d0c662c91e07 |
| Source note | uspto-grants-2014_01 |