HRID471290

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(Cc1cccc(CO)c1)NC[C@H](O[Si](C)(C)C(C)(C)C)c1ccc(OC(=O)OC(C)(C)C)c2[nH]c(=O)ccc12

HCID57989300

未命名化合物

PRODUCTS

生成物

HCID57989095

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID178418406

未命名化合物

溶剂HCID6344

Dichloromethane

CH2Cl2

CONDITIONS

反应条件

温度: 20 °C

PROCEDURE

实验过程

Manganese dioxide (0.6 g) was added to a solution of (R)-tert-butyl 5-(1-(tert-butyldimethylsilyloxy)-2-(1-(3-(hydroxymethyl)phenyl)-2-methylpropan-2-ylamino)ethyl)-2-oxo-1,2-dihydroquinolin-8-yl carbonate (Example 275, step f) (0.44 g) in dichloromethane (30 mL) and the mixture stirred vigorously at 20° C. for 3 hours. The reaction mixture was filtered through diatomaceous earth and the solvent removed under reduced pressure to afford the subtitled compound. Yield 0.42 g.

WORKUP

后处理

filtrationThe reaction mixture was filtered through diatomaceous earth
customthe solvent removed under reduced pressure

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-043a9301a5b54fd7bce6d40c00e2df76
来源数据集: uspto-grants-2014_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08629271B2
来源说明: uspto-grants-2014_01

反应 SMILES

[C:1](=[O:42])([O:7][C:8]1[CH:9]=[CH:10][C:11]([C@@H:19]([O:34][Si:35]([C:38]([CH3:41])([CH3:40])[CH3:39])([CH3:37])[CH3:36])[CH2:20][NH:21][C:22]([CH3:33])([CH3:32])[CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([CH2:30][OH:31])[CH:25]=2)=[C:12]2[C:17]=1[NH:16][C:15](=[O:18])[CH:14]=[CH:13]2)[O:2][C:3]([CH3:6])([CH3:5])[CH3:4]>ClCCl.[O-2].[O-2].[Mn+4]>[C:1](=[O:42])([O:7][C:8]1[CH:9]=[CH:10][C:11]([C@@H:19]([O:34][Si:35]([C:38]([CH3:41])([CH3:40])[CH3:39])([CH3:37])[CH3:36])[CH2:20][NH:21][C:22]([CH3:32])([CH3:33])[CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([CH:30]=[O:31])[CH:25]=2)=[C:12]2[C:17]=1[NH:16][C:15](=[O:18])[CH:14]=[CH:13]2)[O:2][C:3]([CH3:5])([CH3:4])[CH3:6]