HCID 57989068, compound → HCID 57988899, compound

Participants

Reaction Steps

A mixture of 8-(benzyloxy)-5-((R)-1-(tert-butyldimethylsilyloxy)-2-((R)-1-(3-(hydroxymethyl)phenyl)propan-2-ylamino)ethyl)quinolin-2(1H)-one (Example 276, step e) (0.52 g) and 10% palladium on carbon catalyst (0.102 g) in ethanol (36 mL) was hydrogenated at room temperature and at 5 bar pressure of hydrogen for 1.5 hours, then hydrogenated at room temperature and at 1 bar pressure of hydrogen overnight. The mixture was filtered through diatomaceous earth, washing the catalyst well with ethanol, and the combined filtrate and washings were concentrated in vacuo to afford the subtitled compound. Yield 0.42 g. Material used immediately in the next step.

Provenance & Evidence