Hydrochloric Acid → HCID 50991175, compound

Participants

Reaction Conditions

Reaction Steps

A quantity of 5.4 g of 5-[3-(difluoromethyl)-1H-1,2,4-triazol-1-yl]-2,4-dimethylbenzenesulphonyl chloride is dissolved in 25 ml of glacial acetic acid, and 4.6 ml of hydrochloric acid (32% strength) are added. The mixture is heated at 120° C. (reflux). Then 2.53 g of iron powder in portions are added. Following complete reaction, the major part of glacial acetic acid is distilled off, and water and dichloromethane are added. Following phase separation and concentration of the organic phase on a rotary evaporator, and after chromatographic purification (CH2Cl2), 1.9 g (49.5% of theory) of a white solid are obtained.

Provenance & Evidence