Hydroxyamine hydrochloride → HCID 178423542, compound

Participants

Reaction Conditions

Reaction Steps

A solution hydroxylamine hydrochloride (8.70 g) in DMSO was cooled to 15° C., before KOtBu was added in small portions. This mixture was added to a solution of 4-[5-(3,5-Dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-methyl-benzonitrile (5.00 g) in DMSO (20 mL) at room temperature and stirred at 80° C. for 5 h. After completion of the reaction, the mixture was poured onto ice-water and the resulting solid was collected by filtration, washed with water and dried. Chromatography on silica gel yielded the title compound (3.3 g, 61%).

Provenance & Evidence