HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 471389Generated: October 25, 2026
Phosphorus oxychloride → 4-Chloro-6-ethyl-5-iodopyrimidine
https://huagongshe.com/reaction/471389
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 6-ethyl-5-iodo-1H-pyrimidin-4-one | HCID 178437744 | — |
| Product | 4-Chloro-6-ethyl-5-iodopyrimidine | HCID 10978487 | — |
Reaction Steps
A suspension of 90 g (0.36 mol) 4-hydroxy-5-iodo-6-ethyl pyrimidine in 600 mL POCl3 is heated for 1 h at 90° C. The reaction mixture is concentrated under reduced pressure and the residue is poured into crushed ice. The precipitated solid is collected by filtration and washed with water. After drying, the desired product is obtained as a solid (65 g; 67%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08633183B2 |
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| Source dataset | uspto-grants-2014_01 |
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| ORD ID | ord-6cd1afec87c74639a86a29cbb8cdcfc3 |
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| Source note | uspto-grants-2014_01 |
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