Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 471406Generated: October 30, 2026

Potassium Carbonate → 2-Pyridinamine, 5-ethynyl-4-methyl-

https://huagongshe.com/reaction/471406

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium CarbonateHCID 11430—
ReactantHCID 58072883HCID 58072883—
SolventMethanolHCID 887—
Product2-Pyridinamine, 5-ethynyl-4-methyl-HCID 9964100—

Reaction Steps

The title compound is synthesized according to general procedure GP3 starting from 1.8 g (8.8 mmol) 4-methyl-5-trimethylsilanylethynyl-pyridin-2-ylamine and 609 mg (4.4 mmol) K2CO3 in 315 mL MeOH. The product is purified by chromatography on silica gel using a DCM/MeOH gradient. Yield: 1.0 g (86%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08633183B2
Source datasetuspto-grants-2014_01
ORD IDord-5725e52bf836492ca9b17040ad43001e
Source noteuspto-grants-2014_01