HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 5-Ethynyl-6-methylpyridin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 6-Methyl-5-trimethylsilanylethynyl-pyridin-2-ylamine | HCID 59255232 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-Ethynyl-6-methylpyridin-2-amine | HCID 55285938 | — |
Reaction Steps
The title compound is synthesized according to general procedure GP3 starting from 4.3 g (21.0 mmol) 6-methyl-5-trimethylsilanylethynyl-pyridin-2-ylamine and 1.5 g (10.5 mmol) K2CO3 in 30 mL MeOH. The product is purified by chromatography on silica gel using a DCM/MeOH gradient. Yield: 3.6 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08633183B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-58497208515045d296a66d57ed8c6e9d |
| Source note | uspto-grants-2014_01 |