HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 4-Ethyl-5-ethynylpyridin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | HCID 58072749 | HCID 58072749 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-Ethyl-5-ethynylpyridin-2-amine | HCID 57416298 | — |
Reaction Steps
The title compound is synthesized according to general procedure GP3 starting from 3.3 g (15 mmol) 4-ethyl-5-trimethylsilanylethynyl-pyridin-2-ylamine and 1.04 g (7.5 mmol) K2CO3 in 30 mL MeOH. The product is purified by chromatography on silica gel using a DCM/MeOH gradient. Yield: 1.78 g (81%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08633183B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-c9f7421dc8ab47edaeb8f1a50d24be48 |
| Source note | uspto-grants-2014_01 |