N,3,5-Trimethyl-4-nitrobenzamide → 4-amino-N,3,5-trimethylbenzamide

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Reaction Steps

4-Nitro-3,5,N-trimethyl-benzamide (1.0 g, 4.8 mmol) is suspended in methanol (10 mL) and hydrogenated at 3 bar for 3 hours using 10% Palladium on activated carbon (100 mg) as the catalyst. The mixture is filtered through celite and the solvent removed under vacuum to give the title compound (Yield 850 mg).

Provenance & Evidence