HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-3,5-dimethylphenol → (R)-3-(4-Bromo-3,5-dimethyl-phenoxy)-1-methanesulfonyl-pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-3,5-dimethylphenol | HCID 81970 | — |
| Reactant | (3S)-1-(methylsulfonyl)pyrrolidin-3-yl methanesulfonate | HCID 59816083 | — |
| Product | (R)-3-(4-Bromo-3,5-dimethyl-phenoxy)-1-methanesulfonyl-pyrrolidine | HCID 86703888 | — |
Reaction Steps
The title compound is prepared in analogy to Intermediate 36 from 4-Bromo-3,5-dimethylphenol (626 mg, 3.08 mmol) and Methanesulfonic acid (S)-1-methanesulfonyl-pyrrolidin-3-yl ester (300 mg, 1.23 mmol). (Yield: 350 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08633182B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-483e8023e88646b98d3928fe1c10eef0 |
| Source note | uspto-grants-2014_01 |