Ethyl isocyanate → HCID 22381395, compound

HRID 471703Notes

Reaction equation

HRID 471703 reaction equation
[NH2:1][CH2:2][C:3]([CH3:7])([CH3:6])[CH2:4][OH:5].[CH2:8]([N:10]=[C:11]=[O:12])[CH3:9]>O1CCOCC1>[CH2:8]([NH:10][C:11]([NH:1][CH2:2][C:3]([CH3:7])([CH3:6])[CH2:4][OH:5])=[O:12])[CH3:9]

Participants

4

Reactant 2

HCID 8022Ethyl isocyanateHCID 1173261-Propanol, 3-amino-2,2-dimethyl-

Product 1

HCID 22381395HCID 22381395, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of 3-amino-2,2-dimethylpropan-1-ol (1.03 g, 10 mmol) in dry 1,4-dioxane (20 mL) was added dropwise ethyl isocyanate (0.71 g, 10 mmol) at room temperature under nitrogen. The reaction mixture was then stirred at room temperature under nitrogen overnight. The solvent was removed under reduced pressure to give the title compound as colorless oil (1.74 g, 100%). MS 175 (MH+).

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-8ab3eef04a7649ef98655232f640f444
Source dataset
uspto-grants-2014_01
Patent number
US08633186B2

Reaction notes

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