2-Nitro-6-(2-(2-oxopyrrolidin-1-yl)ethoxy)benzonitrile → 2-Amino-6-(2-(2-oxopyrrolidin-1-yl)ethoxy)benzonitrile

HRID 471757Notes

Reaction equation

HRID 471757 reaction equation
[N+:1]([C:4]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12][CH2:13][CH2:14][N:15]2[CH2:19][CH2:18][CH2:17][C:16]2=[O:20])[C:5]=1[C:6]#[N:7])([O-])=O>C(O)C(F)(F)F.FC(F)(F)C(O)C(F)(F)F>[NH2:1][C:4]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12][CH2:13][CH2:14][N:15]2[CH2:19][CH2:18][CH2:17][C:16]2=[O:20])[C:5]=1[C:6]#[N:7]

Participants

3

Reactant 1

HCID 667467332-Nitro-6-(2-(2-oxopyrrolidin-1-yl)ethoxy)benzonitrile

Product 1

HCID 667463222-Amino-6-(2-(2-oxopyrrolidin-1-yl)ethoxy)benzonitrileYield 100%

Reagents, catalysts & solvents 1

HCID 131731144HCID 131731144, compoundSolvent

Procedure

Prepared as in example 254b from 2-nitro-6-(2-(2-oxopyrrolidin-1-yl)ethoxy)benzonitrile (Example 257c) using trifluoroethanol/hexafluoroisopropanol (1:1) as solvent in 100% yield MS 246 (MH+).

Sources & evidence

ORD record
ord-ff05988e737d4e35bb62a74e594a45a5
Source dataset
uspto-grants-2014_01
Patent number
US08633186B2

Reaction notes

Loading…