反应详情

温度

80 °C

To a solution of 2-bromo-4-fluoro-1-nitro-benzene (250 mg, 1.14 mmol) in DMSO (2 mL) was added 7-azabicyclo[2.2.1]heptane (182 mg, 1.36 mmol) portion-wise. The reaction was stirred at 80° C. for 24 h. The reaction was quenched with water and the aqueous layer was extracted with dichloromethane. The combined organic extracts were washed with 1 N HCl, dried over MgSO4, filtered and concentrated in vacuo to provide 7-(3-bromo-4-nitrophenyl)-7-azabicyclo[2.2.1]heptane (864 mg, 98% yield). LC/MS m/z 298.5 [M+H]+.

1. customThe reaction was quenched with water
2. extractionthe aqueous layer was extracted with dichloromethane
3. washThe combined organic extracts were washed with 1 N HCl
4. dry with materialdried over MgSO4
5. filtrationfiltered
6. concentrationconcentrated in vacuo