反应详情

To a solution of 4-nitro-3-(tetrahydrofuran-3-yloxy)-benzamide (4.77 g, 18.15 mmol) in ethanol (200 ml) was added 10% palladium on carbon (0.5 g, 10% w/w) and the flask rinsed with an additional portion of ethanol (20 ml). The reaction was then purged with a nitrogen atmosphere, placed under a H2 (g) atmosphere and stirred at room temperature for 18 hours. The reaction was then purged with N2 (g) and filtered through a celite pad. The pad was washed with ethanol (100 ml) and the filtrate concentrated to dryness in vacuo to give the title compound as a white solid (4.22 g, 18.9 mmol, 100% corrected). LCMS: [M+H]+=223, Rt=1.01 min, 100% purity

1. washthe flask rinsed with an additional portion of ethanol (20 ml)
2. customThe reaction was then purged with a nitrogen atmosphere
3. customThe reaction was then purged with N2 (g)
4. filtrationfiltered through a celite pad
5. washThe pad was washed with ethanol (100 ml)
6. concentrationthe filtrate concentrated to dryness in vacuo