反应详情

A mixture of ethyl 6-bromo-4-hydroxy-8-methyl-3-quinolinecarboxylate (1.89 g, 6.09 mmol) and 6 N NaOH (1.22 g, 30.45 mmol, 5.1 mL) in ethanol (30 mL) was heated at reflux for 2.0 h and concentrated in vacuo. The residue was diluted with water and acidified with 6 N HCl to pH 4. The resulting solid was filtered, washed with water and diethyl ether, and dried overnight in a Buchner funnel to give the title compound (1.72 g, 99%) as a tan solid. MS (ES)+ m/e 282 [M+H].

1. temperaturewas heated
2. temperatureat reflux for 2.0 h
3. concentrationconcentrated in vacuo
4. additionThe residue was diluted with water
5. filtrationThe resulting solid was filtered
6. washwashed with water and diethyl ether
7. customdried overnight in a Buchner funnel