反应详情

温度

260 °C

A mixture of 6-bromo-4-hydroxy-8-methyl-3-quinolinecarboxylic acid (1.80 g, 6.36 mmol) and Dowtherm A (10 mL) was heated at 260° C. for 1.0 h. The reaction was cooled, triturated with hexanes, filtered and dried in a Buchner funnel to give the title compound (1.43 g, 95%) as a tan solid. MS (ES)+ m/e 238 [M+H].

1. temperatureThe reaction was cooled
2. customtriturated with hexanes
3. filtrationfiltered
4. customdried in a Buchner funnel