1H-indazol-3-amine → [2-(2-Chloro-phenyl)-pyrido[3,4-d]pyrimidin-4-yl]-(1H-indazol-3-yl)-amine

Participants

Role	Name	HCID	Charge
Reactant	1H-indazol-3-amine	HCID 13399	—
Reactant	4-Chloro-2-(2-chloro-phenyl)-pyrido[3,4-d]pyrimidine	HCID 21939210	—
Product	[2-(2-Chloro-phenyl)-pyrido[3,4-d]pyrimidin-4-yl]-(1H-indazol-3-yl)-amine	HCID 21939198	—

Reaction Steps

Prepared from 4-Chloro-2-(2-chloro-phenyl)-pyrido[3,4-d]pyrimidine (100 mg, 0.36 mmol) and 1H-indazol-3-ylamine (88 mg, 0.66 mmol). Purification by preparative HPLC afforded the title compound as a yellow, di-TFA salt (72 mg, 33% yield). HPLC-Method A, Rt 3.21 min; 1H NMR (DMSO, 500 MHz): δ 12.95 (1H, s), 10.90 (1H, bs), 9.25 (1H, s), 8.75 (1H, m), 8.55 (1H, m), 7.65 (1H, m), 7.55 (1H, m), 7.50-7.30 (5H, m), 7.00 (1H, m); MS (m/z), MH+ 373.1.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08633210B2
Source dataset	uspto-grants-2014_01
ORD ID	ord-85264c7d6e2a4bae8f572f3ea4881af5
Source note	uspto-grants-2014_01