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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 47220Generated: October 29, 2026

Sodium ethoxide → 3-Ethoxymethyl-5-(4-trifluoromethyl-3-pyridyl)-1,2,4-oxadiazole

https://huagongshe.com/reaction/47220

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium ethoxideHCID 2723922—
Reactant3-Iodomethyl-5-(4-trifluoromethyl-3-pyridyl)-1,2,4-oxadiazoleHCID 22744094—
Product3-Ethoxymethyl-5-(4-trifluoromethyl-3-pyridyl)-1,2,4-oxadiazoleHCID 9795501—

Reaction Steps

3-Iodomethyl-5-(4-trifluoromethyl-3-pyridyl)-1,2,4-oxadiazole (0.5 g) was dissolved in a freshly prepared solution of sodium ethoxide (30 mg of sodium in 7 ml of ethanol), and the mixture was stirred at room temperature for 6 hours.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06699853B2
Source datasetuspto-grants-2004_03
ORD IDord-dcd801376dc94a32b1b20d493cbefdc7
Source noteuspto-grants-2004_03