HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-fluoro-6,10b-dihydro-1aH-dibenzo-[3,4:6,7]cyclohept[1,2-b]oxirene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Isopropanol hydrochloride | HCID 21912024 | — |
| Reactant | 2-fluoro-5H-dibenzo[a,d]cycloheptene | HCID 22744162 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 3-fluoro-6,10b-dihydro-1aH-dibenzo-[3,4:6,7]cyclohept[1,2-b]oxirene | HCID 86588700 | 43% |
Reaction Steps
Compound 1 was dissolved in diethyl ether (20 ml) and converted into the hydrochloric acid salt (1:1) by dropwise addition of 6 N HCl/2-propanol. The solvent was evaporated. The residue was triturated under boiling 2-propanone, filtered off and dried, yielding 2.17 g (43%) of (±)-(2α,3aβ,12bα)-11-fluoro-3,3a,8,12b-tetrahydro-N, N-dimethyl-2H-dibenzo[3,4:6,7]cyclohepta[1,2-b]furan-2-methanamine hydrochloride (compound 2; mp. 239.1° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06699858B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-26278836630c419db0cc219d547fda6f |
| Source note | uspto-grants-2004_03 |