4-(4-Bromophenyl)morpholine → HCID 49838138, compound

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[8-(4-Methanesulfonyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-(4-morpholin-4-yl-phenyl)-amine and [8-(4-methanesulfonyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-phenyl-amine were prepared from 8-(4-methanesulfonyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine (100.0 mg, 0.3468 mmol) and 4-(4-bromo-phenyl)-morpholine (100.0 mg, 0.4130 mmol) in a manner analogous to Example 2d. [8-(4-Methanesulfonyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-(4-morpholin-4-yl-phenyl)-amine was isolated as a pale yellow solid (0.063 g, 40%). MP=244-246° C. 1H NMR (400 MHz, CDCl3, δ, ppm): 8.49-8.45 (m, 1H), 8.25-8.20 (m, 2H), 8.11-8.06 (m, 2H), 7.63 (dd, J=7.4, 0.9 Hz, 1H), 7.53-7.48 (m, 2H), 6.99 (t, J=7.0 Hz, 1H), 6.97-6.93 (m, 2H), 6.73 (s, 1H), 3.90-3.86 (m 4H), 3.14-3.09 (m, 7H). MS=450 (MH)+.

Provenance & Evidence