HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-6-Chloropyrazine → 6-(4-Methylsulfonylphenyl)pyrazin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-6-Chloropyrazine | HCID 118458 | — |
| Reactant | 4-(Methanesulfonyl)phenylboronic acid | HCID 2734364 | — |
| Product | 6-(4-Methylsulfonylphenyl)pyrazin-2-amine | HCID 67478761 | — |
Reaction Steps
6-(4-Methanesulfonyl-phenyl)-pyrazin-2-ylamine was prepared from 6-chloro-pyrazin-2-ylamine and (4-methylsulfonylphenyl)boronic acid in a manner analogous to Step 2c to afford an off-white solid (99%). 1H NMR (400 MHz, (D3C)2SO, δ, ppm): 8.39 (s, 1H), 8.25 (d, 7.6 Hz, 2H) 8.02 (d, 7.6 Hz, 2H), 7.95 (s, 1H), 6.70 (bs, 2H), 3.26 (s, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08633173B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-c79656b072944852869aef1d9a8be950 |
| Source note | uspto-grants-2014_01 |