4-(3-bromobenzyl)morpholine → HCID 67481477, compound

Participants

Reaction Steps

[5-(4-Methanesulfonyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-(3-morpholin-4-ylmethyl-phenyl)-amine was prepared from 5-(4-methanesulfonyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine (75.0 mg, 0.260 mmol) and 4-(3-bromo-benzyl)-morpholine (75.0 mg, 0.293 mmol) with 2,2′-bis-dicyclohexylphosphanyl-biphenyl (29.0 mg, 0.0530 mmol) as the ligand in a manner analogous to Example 2d. Product isolated as yellow foam (0.042 g, 35%). 1H NMR (400 MHz, CDCl3, δ, ppm): 8.27 (d, J=8.5 Hz, 2H), 8.14 (d, J=8.5 Hz, 2H), 7.59-7.47 (m, 4H), 7.29 (t, J=7.8 Hz, 1H), 7.06 (dd, J=4.5, 3.9 Hz, 1H), 6.97 (d, J=7.4 Hz, 1H), 6.94 (s, 1H), 3.73-3.67 (m, 4H), 3.50 (s, 2H), 3.15 (s, 3H), 2.50-2.42 (m, 4H). MS=464 (MH)+.

Provenance & Evidence