HCID 43458516, compound → HCID 67479285, compound

HRID 472454Notes

Reaction equation

HRID 472454 reaction equation
Br[C:2]1[C:3]2[N:4]([N:8]=[C:9]([Cl:11])[N:10]=2)[CH:5]=[CH:6][CH:7]=1.[NH2:12][C:13]1[CH:25]=[CH:24][CH:23]=[CH:22][C:14]=1[CH2:15][N:16]([CH3:21])[S:17]([CH3:20])(=[O:19])=[O:18]>>[Cl:11][C:9]1[N:10]=[C:3]2[C:2]([NH:12][C:13]3[CH:25]=[CH:24][CH:23]=[CH:22][C:14]=3[CH2:15][N:16]([CH3:21])[S:17]([CH3:20])(=[O:19])=[O:18])=[CH:7][CH:6]=[CH:5][N:4]2[N:8]=1

Participants

3

Reactant 2

HCID 43458516HCID 43458516, compoundHCID 674813708-Bromo-2-chloro-[1,2,4]triazolo[1,5-a]pyridine

Product 1

HCID 67479285HCID 67479285, compound

Procedure

171 c) N-[2-(2-Chloro-[1,2,4]triazolo[1,5-a]pyridin-8-ylamino)-benzyl]-N-methyl-methanesulfonamide was prepared from 8-bromo-2-chloro-[1,2,4]triazolo[1,5-a]pyridine (500.0 mg, 2.151 mmol) and N-(2-amino-benzyl)-N-methyl-methanesulfonamide (507.0 mg, 2.366 mmol) in a manner analogous to Exmaple 2d. Product isolated as a tan foam (0.53 g, 67%). 1H NMR (400 MHz, CDCl3, δ, ppm): 8.01 (d, J=6.4 Hz, 1H), 7.48-7.41 (m, 2H), 7.38 (t, J=7.4 Hz, 1H), 7.21 (t, J=7.4 Hz, 1H), 7.10 (s, 1H), 6.90-6.81 (m, 2H), 4.36 (s, 2H), 3.02 (s, 3H), 2.76 (s, 3H). MS=366 (MH)+.

Sources & evidence

ORD record
ord-ce64f1028b4e45b59355f05d456b13f9
Source dataset
uspto-grants-2014_01
Patent number
US08633173B2

Reaction notes

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