Trifluoroacetic acid → HCID 67481553, compound

Participants

Reaction Steps

7-[8-(2-Chloro-5-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridine-2-ylamino]-1,2,4,5-tetrahydro-3-benzazepine-3-carboxylic acid tert-butyl ester (0.089 mg, 0.16 mmol) in dichloromethane (2.0 mL) was added trifluoroacetic acid (0.10 mL, 1.6 mmoL) dropwise at room temperature, and the reaction was stirred at room temperature for 30 min. The solvent was evaporated, and the residue was diluted with dichloromethane, washed with 5% sodium carbonate solution, brine, dried over sodium sulfate, and concentrated to give the product [8-(2-chloro-5-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridine-2-yl]-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-amine (0.052 g, 83%). MS=558 (MH)+.

Provenance & Evidence