2-Fluoro-5-(trifluoromethyl)phenylboronic acid → HCID 67481476, compound

HRID 472555Notes

Reaction equation

HRID 472555 reaction equation
Br[C:2]1[C:3]2[N:4]([N:8]=[C:9]([Cl:11])[N:10]=2)[CH:5]=[CH:6][CH:7]=1.[F:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][C:14]=1B(O)O>>[Cl:11][C:9]1[N:10]=[C:3]2[C:2]([C:14]3[CH:15]=[C:16]([C:19]([F:21])([F:22])[F:20])[CH:17]=[CH:18][C:13]=3[F:12])=[CH:7][CH:6]=[CH:5][N:4]2[N:8]=1

Participants

3

Reactant 2

HCID 27633012-Fluoro-5-(trifluoromethyl)phenylboronic acidHCID 674813708-Bromo-2-chloro-[1,2,4]triazolo[1,5-a]pyridine

Product 1

HCID 67481476HCID 67481476, compound

Procedure

2-Chloro-8-(2-fluoro-5-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridine was prepared from 8-bromo-2-chloro-[1,2,4]triazolo[1,5-a]pyridine and 2-fluoro-5-trifluoromethylphenylboronic acid in a manner analogous to Example 2c (0.150 g, 22%). MP=88-89° C. MS=317 (MH)+.

Sources & evidence

ORD record
ord-9936bb5ae4a44cb4ae4dbf3cd1f8920a
Source dataset
uspto-grants-2014_01
Patent number
US08633173B2

Reaction notes

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