HCID 67478796, compound → HCID 67481456, compound

HRID 472559Notes

Reaction equation

HRID 472559 reaction equation
Br[C:2]1[C:3]2[N:4]([N:8]=[C:9]([Cl:11])[N:10]=2)[CH:5]=[CH:6][CH:7]=1.[CH3:12][O:13][C:14]1(B(O)O)[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][NH:15]1>>[Cl:11][C:9]1[N:10]=[C:3]2[C:2]([C:19]3[C:14]([O:13][CH3:12])=[N:15][CH:16]=[C:17]([C:20]([F:23])([F:21])[F:22])[CH:18]=3)=[CH:7][CH:6]=[CH:5][N:4]2[N:8]=1

Participants

3

Reactant 2

HCID 67478796HCID 67478796, compoundHCID 674813708-Bromo-2-chloro-[1,2,4]triazolo[1,5-a]pyridine

Product 1

HCID 67481456HCID 67481456, compound

Procedure

2-Chloro-8-(2-methoxy-5-trifluoromethyl-pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine was prepared from 8-bromo-2-chloro-[1,2,4]triazolo[1,5-a]pyridine and 2-methoxy-5-trifluoromethylpyridineboronic acid in a manner analogous to Example 2c (0.46 g, 65%). MP=183-185° C. MS=329 (MH)+.

Sources & evidence

ORD record
ord-1c1a5fc140fe433888ef98fd0bf302eb
Source dataset
uspto-grants-2014_01
Patent number
US08633173B2

Reaction notes

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