8-Bromo-2-chloro-[1,2,4]triazolo[1,5-a]pyridine → HCID 67481452, compound

HRID 472572Notes

Reaction equation

HRID 472572 reaction equation
Br[C:2]1[C:3]2[N:4]([N:8]=[C:9]([Cl:11])[N:10]=2)[CH:5]=[CH:6][CH:7]=1.[CH3:12][N:13]1[C:21]2[CH:20]=[CH:19][CH:18]=[C:17](B3OC(C)(C)C(C)(C)O3)[C:16]=2[CH2:15][NH:14]1>>[Cl:11][C:9]1[N:10]=[C:3]2[C:2]([C:17]3[CH:18]=[CH:19][CH:20]=[C:21]4[C:16]=3[CH:15]=[N:14][N:13]4[CH3:12])=[CH:7][CH:6]=[CH:5][N:4]2[N:8]=1

Participants

3

Reactant 2

HCID 674813708-Bromo-2-chloro-[1,2,4]triazolo[1,5-a]pyridineHCID 131731147HCID 131731147, compound

Product 1

HCID 67481452HCID 67481452, compound

Procedure

2-Chloro-8-(1-methyl-1H-indazol-4-yl)-[1,2,4]triazolo[1,5-a]pyridine was prepared from 8-bromo-2-chloro-[1,2,4]triazolo[1,5-a]pyridine and 1-methyl-2H-indazole-4-boronic acid pinacol ester in a manner analogous to Example 2c (0.36 g, 59%). MS=284 (MH)+.

Sources & evidence

ORD record
ord-8620b9989d194829a6ec454817f59624
Source dataset
uspto-grants-2014_01
Patent number
US08633173B2

Reaction notes

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