HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzylamine → 4-Phenylacetyl-1H-pyrrole-2-carboxylic acid benzylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | 2,2,2-trichloro-1-[4-(2-phenylacetyl)-1H-pyrrol-2-yl]-1-ethanone | HCID 2763608 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-Phenylacetyl-1H-pyrrole-2-carboxylic acid benzylamide | HCID 12125417 | — |
Reaction Steps
To a solution of compound 1 (1 equivalent) in DMF, at ambient temperature, was added benzylamine (1.2 equivalents). After 24 hours, the solvent was evaporated and the crude product 2 was utilized without purification. HPLC using method B (as described below for Example 5) provided retention time of 3.8 minutes. FIA/MS (M+1) 319.3, (M−1) 317.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06699865B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-8ff5ace2d3b048e3b99a023fa6e2796c |
| Source note | uspto-grants-2004_03 |