Trifluoroacetic acid → HCID 59612463, compound

Participants

Reaction Steps

[8-(4-Difluoromethyl-2-methoxy-phenyl)-[1,2,4]-triazolo[1,5-a]pyridin-2-yl]-(4-piperidin-4-yl-phenyl)-amine was prepared from 4-{4-[8-(4-difluoromethyl-2-methoxy-phenyl)-[1,2,4]-triazolo[1,5-a]pyridin-2-ylamino]-phenyl}-piperidine-1-carboxylic acid tert-butyl ester (0.191 g, 0.348 mmol) and trifluoroacetic acid (0.500 mL) in a manner analogous to Example 312 to give product (0.170 g, 99%). MP=208-212° C. 1H NMR (400 MHz, (D3C)2SO, δ, ppm): 9.57 (s, 1H), 8.78 (d, 1H), 7.70 (d, 1H), 7.55 (m, 3H), 7.32 (s, 1H), 7.25 (m, 1H), 7.15 (m, 3H), 7.10 (br m, 1H), 3.78 (s, 3H), 3.28 (br m, 3H), 2.92 (m, 2H), 2.65 (m, 1H), 1.83 (m, 2H), 1.65 (m, 2H): MS=450 (MH)+.

Provenance & Evidence