Trifluoroacetic acid → HCID 59612407, compound

Participants

Reaction Steps

[8-(3-Methoxy-phenyl)-[1,2,4]-triazolo[1,5-a]pyridin-2-yl]-(4-piperidin-4-yl-phenyl)-amine was prepared from 4-{4-[8-(3-methoxy-phenyl)-[1,2,4]-triazolo[1,5-a]pyridin-2-ylamino]-phenyl}-piperidine-1-carboxylic acid tert-butyl ester (0.405 g, 0.812 mmol) and trifluoroacetic acid (2 mL) in a manner analogous to Example 312 to give product (0.150 g, 46%). MP=88-90° C. 1H NMR (400 MHz, (D3C)2SO, δ, ppm): 9.60 (s, 1H), 8.78 (d, 1H), 7.85 (m, 2H), 7.65 (m, 3H), 7.40 (m, 1H), 7.15 (m, 3H), 7.05 (m, 1H), 3.86 (s, 3H), 3.00 (m, 2H), 2.55 (m, 3H), 2.35 (br m, 1H), 1.65 (m, 2H), 1.45 (m, 2H). MS=400 (MH)+.

Provenance & Evidence