2-chloro-N,N-dimethylacetamide → HCID 59612607, compound

Participants

Reaction Steps

2-(4-{4-[8-(3-Methoxy-phenyl)-[1,2,4]-triazolo[1,5-a]pyridin-2-ylamino]-phenyl}-piperidin-1-yl)-N,N-dimethyl-acetamide was prepared from [8-(3-methoxy-phenyl)-[1,2,4]-triazolo[1,5-a]pyridin-2-yl]-(4-piperidin-4-yl-phenyl)-amine (0.150 g, 0.375 mmol) and 2-chloro-N,N-dimethyl-acetamide (0.057 mL, 0.563 mmol) in a manner analogous to Example 313 to give product (0.065 g, 36%). MP=178-179° C. 1H NMR (400 MHz, (D3C)2SO, δ, ppm): 9.61 (s, 1H), 8.78 (d, 1H), 7.85 (d, 1H), 7.80 (s, 1H), 7.65 (m, 3H), 7.40 (m, 1H), 7.15 (m, 3H), 7.05 (m, 1H), 3.86 (s, 3H), 3.15 (s, 2H), 3.05 (s, 3H), 2.92 (m, 2H), 2.85 (s, 3H), 2.40 (m, 1H), 2.10 (m, 2H), 1.65 (m, 4H). MS=485 (MH)+.

Provenance & Evidence