tert-Butyl 4-(4-aminophenyl)piperidine-1-carboxylate → HCID 49839726, compound

Participants

Reaction Steps

4-{4-[8-(3-Dimethylamino-phenyl)-[1,2,4]-triazolo[1,5-a]pyridin-2-ylamino]-phenyl}-piperidine-1-carboxylic acid tert-butyl ester was prepared from [3-(2-chloro-[1,2,4]-triazolo[1,5-a]pyridin-8-yl)-phenyl]-dimethyl-amine (0.250 g, 0.917 mmol) and 4-(4-amino-phenyl)-piperidine-1-carboxylic acid tert-butyl ester (0.304 g, 1.10 mmol) in a manner analogous to Example 311a and 311b to give product (0.288 g, 61%). MP=95-98° C. 1H NMR (400 MHz, (D3C)2SO, δ, ppm): 9.57 (s, 1H), 8.74 (d, 1H), 7.82 (d, 1H), 7.62 (d, 2H), 7.50 (s, 1H) 7.32 (m, 2H), 7.15 (m, 3H), 6.80 (d, 1H), 4.05 (m, 2H), 3.00 (s, 6H), 2.80 (br m, 2H), 2.60 (m, 1H), 1.75 (m, 2H), 1.45 (m, 2H), 1.41 (s, 9H). MS=513 (MH)+.

Provenance & Evidence