Acetic Acid → HCID 86651616, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of Methyl 4-[(2R,4R)-1-{[{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]carbonyl}-4-{[(1,1-dimethylethyl)sulfinyl]amino}-2-(4-fluoro-2-methylphenyl)-4-piperidinyl]-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2-butenoate (intermediate 5, 100 mg, 0.119 mmol) and Acetic acid (0.014 mL, 0.239 mmol) in Acetonitrile (2 mL) was added Cesium Fluoride (58.0 mg, 0.382 mmol, Aldrich) and the reaction mixture was stirred at 25° C. for 5 hrs. NaHCO3 saturated solution was added very carefully and the mixture was extracted with EtOAc (3×). The combined organic phases were dried (Na2SO4) and evaporated to dryness. The crude was purified by flash chromatography on silica with SP1 (Biotage) system (from 1:0 to 0:1 Cyclohexane/EtOAc) to give the title compound (64.4 mg, 0.089 mmol, 75% yield) as a white foam. 1H NMR (400 MHz, DMSO-d6) δ ppm 7.97 (s, 1H) 7.58-7.72 (m, 2H) 7.08-7.22 (m, 1H) 6.88 (d, 1H) 6.70 (t, 1H) 5.25-5.38 (m, 1H) 5.03 (s, 1H) 4.35-4.50 (m, 1H) 3.72 (s, 3H) 2.86-3.22 (m, 4H) 2.65 (s, 3H) 2.36 (s, 3H) 1.44 (d, 3H) 1.32-2.12 (m, 6H) 1.19 (s, 9H). The sample consists of two species ratio ˜70:30 (see signals of OMe at 3.71 ppm, 3.66 ppm). UPLC: 2 peaks Rt 0.87 and 0.93 mins with the expected mass m/z=724 [M+H]+.

Provenance & Evidence