HCID 58169881, compound → HCID 58169871, compound

Participants

Reaction Steps

3-methyl 1-(phenylmethyl) (5S,7R)-8-{[{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]carbonyl}-7-(4-fluoro-2-methylphenyl)-2-oxo-1,8-diazaspiro[4.5]decane-1,3-dicarboxylate (Intermediate 34, 78 mg) was dissolved in Methanol (3 ml), Pd/C (8.83 mg, 8.30 μmol) was added and the suspension was left stirring at rt, under a H2 atmosphere (1 atm), for 1 hr. The Pd was filtered out and the solvent was removed obtaining the title compound (60 mg); UPLC: Rt=0.82 mins, m/z=618 [M+H]+.

Provenance & Evidence