Hydrochloric Acid → HCID 86651620, compound

Participants

Reaction Steps

To a solution of (2S,5S,7R)-N8-{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-7-(4-fluoro-2-methylphenyl)-N8-methyl-1,8-diazaspiro[4.5]decane-2,8-dicarboxamide (Example 13, 67 mg, 0.113 mmol) in Diethyl ether (1 ml) was added 1M HCl in Et2O (200 μl, 0.200 mmol) and the resulting mixture was stirred for 30 mins. Then the solvent was evaporated to dryness to give the title compound (68.2 mg, 0.109 mmol, 96% yield) as a white solid. 1H NMR (500 MHz, DMSO-d6) δ ppm 9.67 (br. s., 1H) 8.34 (br. s., 1H) 7.87-8.00 (m, 2H) 7.66 (s, 1H) 7.55 (s, 2H) 7.13-7.32 (m, 1H) 6.94 (d, 1H) 6.76-6.89 (m, 1H) 5.25-5.43 (m, 1H) 4.07-4.38 (m, 2H) 3.40-3.51 (m, 1H) 2.84 (s, 3H) 2.71-2.91 (m, 1H) 2.33 (s, 3H) 1.78-2.58 (m, 8H) 1.50 (d, 3H); HPLC: Rt=4.93 mins (free base); MS: peak @ m/z=589 [M+H]+ and 611 [M+Na]+ (free base).

Provenance & Evidence