Cyclopentylamine → N-(5-Chloro-2,4-dimethoxy-phenyl)-2-{2,4-dioxo-3-[4-(phenethylcarbamoyl-methyl)-phenyl]-3,4-dihydro-2H-quinazolin-1-yl}-acetamide

Participants

Reaction Steps

This compound is made analogously to Example 1-2 by replacing {1-[(5-chloro-2,4-dimethoxy-phenylcarbamoyl)-methyl]-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl}-acetic acid (Intermediate A) with ({2,4-dioxo-3-[4-(phenethylcarbamoyl-methyl)-phenyl]-3,4-dihydro-2H-quinazolin-1-yl}-acetic acid) (Intermediate D) and by replacing cyclopentylamine with 5-chloro-2,4-dimethoxy-phenylamine to afford the title compound. The reaction is carried out using DMF as the solvent.

Provenance & Evidence