Bis(tributyltin) oxide → (4-{1-[(5-Chloro-2,4-dimethoxy-phenylcarbamoyl)-methyl]-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl}-phenyl)-acetic acid

Participants

Reaction Conditions

Reaction Steps

(4-[1-[(5-Chloro-2,4-dimethoxy-phenylcarbamoyl)-methyl]-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl}-phenyl)-acetic acid ethyl ester (Intermediate K) (105.4 mg, 0.19 mmol) is added to a stirred solution of Bis(tributyltin)oxide) (2 eq, 0.38 mmol, 193.1 μL) in toluene (10 ml). The mixture is heated at reflux at 120° C. for 72 hours. The toluene is removed in vacuo, and the red/brown oily residue is partitioned between EtOAc and saturated NaHCO3 (5 ml). The resultant precipitate is filtered, washed with NaHCO3, EtOAc, 1M HCl, water, and dried to give the title compound, [M+H]+ 524

Provenance & Evidence