Trifluoroacetic acid → 2-[3-(2-Amino-ethyl)-2,4-dioxo-3,4-dihydro-2H-quinazolin-1-yl]-N-(5-chloro-2,4-dimethoxy-phenyl)-acetamide trifluoroacetate

Participants

Reaction Steps

(2-{1-[(5-Chloro-2,4-dimethoxy-phenylcarbamoyl)-methyl]-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl}-ethyl)-carbamic acid tert-butyl ester (100 mg, 1.88 mmol) is taken up in DCM (2 ml) and treated with TFA (2 ml). The reaction is stirred at RT for 2 hours and then treated with EtOAc (20 ml). After 5 minutes, the white solid present is filtered, washed with EtOAc, ether and dried under vacuum to give the title compound as a white solid; [M+H]+ 433,

Provenance & Evidence