Potassium Carbonate → {1-[(5-chloro-2,4-dimethoxy-phenylcarbamoyl)-methyl]-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl}-acetic acid methyl ester

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Reaction Steps

A mixture of (2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-acetic acid methyl ester (1 g, 4.27 mmol), K2CO3 (910 mg, 6.404 mmol) and 2-bromo-N-(5-chloro-2,4-dimethoxy-phenyl)-acetamide (Intermediate C) (1.42 g, 4.697 mmol) in dry DMF (6 ml) is left to stir at RT overnight. The reaction mixture is diluted with water resulting in a cream precipitate which is filtered, washed with water and dried under vacuum to give the title compound as a pale yellow solid [M+H]+ 462.

Provenance & Evidence