Acetone → HCID 54767922, compound

Participants

Reaction Conditions

Reaction Steps

N-(4-{4-amino-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]thieno[3,2-c]pyridin-3-yl}phenyl)-N′-(3-fluorophenyl)urea free base solids (399.87 mg) was added to 20 mL of acetone:water mixture (75:25 v:v) and heated with stirring at 70° C. for 30 minutes. The sample remained as a suspension. Citric acid (1.2 mL, 1 M) solution in water was added with continued stirring at 70° C. At the end of approximately one hour, the sample was almost completely dissolved. The sample was allowed to cool slowly to ambient temperatures overnight. The suspension was filtered through a 0.22 micron PTFE syringe filter. The filtrate was evaporative cooled by applying vacuum. Amorphous material precipitated forming a milky suspension, which turned into a “gummy” material (sticky mass) after several minutes. The sample was sonicated for approximately thirty minutes, upon which crystallization occurred. The crystalline solid was collected by vacuum filtration.

Provenance & Evidence