Acetone → HCID 54767922, compound

Participants

Reaction Conditions

Reaction Steps

N-(4-{4-amino-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]thieno[3,2-c]pyridin-3-yl}phenyl)-N′-(3-fluorophenyl)urea free base solids (398.06 mg) was added to 20 mL of acetone:water mixture (75:25 v:v) and heated with stirring at 70° C. for 30 minutes. The sample remained as a suspension. Citric acid (1.2 mL, 1 M) solution in water was added with continued stirring at 70° C. After adding the citric acid solution, slight more of the solid was observed to dissolve. Within 12 minutes after the addition of citric acid, a suspension was formed. The suspension was stirred at 70° C. for approximately one hour. The solid was isolated by vacuum filtration.

Provenance & Evidence