Ammonia → HCID 67445776, compound

Participants

Reaction Steps

3-(5-Methoxy-benzo[b]thiophen-2-yl)-8-aza-bicyclo[3.2.1]oct-2-ene (0.30 g, 1.105 mmol) was solved in dichloromethane (25 ml) and was cooled on an ice-bath. Borontribromide (1 M, 2.21 ml, 2.21 mmol) was added dropwise under cooling, followed by stirring for 15 hours at room-temperature. Water (40 ml) was added and the mixture was made alkaline by adding aqueous ammonia. The product was filtered and was recrystallised with ethanol (25 ml, 96%) and HCl in ethanol (0.5 ml, 3 M). Yield 0.15 g (46%).

Provenance & Evidence