Methanol → HCID 66693001, compound

HRID 472818Notes

Reaction equation

HRID 472818 reaction equation
[OH:1][CH:2]([C:6]1[C:7]([CH3:28])=[N:8][C:9]2[N:10]([N:19]=[C:20]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH:21]=2)[C:11]=1[C:12]1[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][CH:13]=1)[C:3]([OH:5])=[O:4].[CH3:29]O>>[OH:1][CH:2]([C:6]1[C:7]([CH3:28])=[N:8][C:9]2[N:10]([N:19]=[C:20]([C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=3)[CH:21]=2)[C:11]=1[C:12]1[CH:13]=[CH:14][C:15]([CH3:18])=[CH:16][CH:17]=1)[C:3]([O:5][CH3:29])=[O:4]

Participants

3

Reactant 2

HCID 887MethanolHCID 66693255HCID 66693255, compound

Product 1

HCID 66693001HCID 66693001, compound

Conditions

Temperature
40 °C

Procedure

To a solution of 2-hydroxy-2-(5-methyl-2-phenyl-7-p-tolylpyrazolo[1,5-a]pyrimidin-6-yl)acetic acid (6 mg, 0.016 mmol) in methanol (2 mL) was added thionyl chroride (0.0023 mL, 0.032 mmol). The reaction mixture was stirred at 40° C. for 16 hrs. The solvent was evaporated to give the title compound. The crude product was used directly for next step.

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-f32335b9d9f64b13bba01850cd543987
Source dataset
uspto-grants-2014_01
Patent number
US08633200B2

Reaction notes

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