Potassium Carbonate → HCID 66691549, compound

Participants

Reaction Conditions

Reaction Steps

To a 2-5 ml microwave tube was added methyl 2-(3-bromo-7-chloro-5-methyl-2-phenylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate (290 mg, 0.621 mmol), tetrakis(triphenylphosphine)palladium(0) (71.8 mg, 0.062 mmol), 2-(8-fluoro-5-methylchroman-6-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (200 mg, 0.683 mmol), DMF (2 mL) followed by 2M K2CO3 solution (200 μl). The reaction mixture was heated in a microwave reactor at 110° C. for 40 min. The reaction mixture was filtered and the filtrate was purified by silica gel chromatography to afford (35 mg, 9.4%) of the title compound. 1H NMR (500 MHz, CHLOROFORM-d) δ 7.90 (dd, J=8.1, 1.4 Hz, 2H), 7.53-7.32 (m, 3H), 6.86 (d, J=10.7 Hz, 1H), 5.02 (s, 1H), 4.48-4.18 (m, 2H), 3.64 (s, 3H), 2.82 (s, 3H), 2.75 (t, J=6.4 Hz, 2H), 2.20-2.12 (m, 2H), 1.84 (s, 3H), 1.16 (s, 9H).

Provenance & Evidence