Dichloromethane → Methyl 2-tert-butoxy-2-(3,7-dichloro-2,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)acetate

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Reaction Steps

To a suspension of methyl 2-(3,7-dichloro-2,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)-2-hydroxyacetate (80 mg, 0.26 mmol) in tert-butyl acetate (1.5 mL) at room temperature was added CH2Cl2 (1.5 mL) followed by perchloric acid (40 mg, 2.1 mmol). The reaction mixture was stirred for 2 h at room temperature. The reaction mixture was diluted with ethyl acetate (15 mL). The organic phase was washed with saturated NaHCO3 (2×10 mL), followed by water (1×10 mL) and dried over sodium sulfate. The solvent was evaporated. Purification by silica gel chromatography provided the title compound (85 mg, 90%). Used as is in the next step.

Provenance & Evidence