Methyl {4-[(cyclohexylmethyl)amino]-3-nitrophenyl}carbamate → Methyl {3-amino-4-[(cyclohexylmethyl)amino]phenyl}carbamate

Participants

Reaction Steps

Methyl {4-[(cyclohexylmethyl)amino]-3-nitrophenyl}carbamate (1.05 g, 3.42 mmol) was dissolved in 30 mL of EtOAc containing a catalytic amount of 10% Pd/C. The solution was shaken in a Parr hydrogenation apparatus under H2 atmosphere (40 psi) at rt overnight. The solution was filtered through Celite and the solvent evaporated. The product was directly used for the next step without further purification. Yield: 950 mg (99%). MS (ESI) (M−1-H)+ 277.9.

Provenance & Evidence