Cesium carbonate → 6'-Bromospiro[cyclohexane-1,2'-indene]-1',4(3'H)-dione

참여 물질

역할	이름	HCID	투입량
반응물	Cesium carbonate	HCID 10796	—
반응물	6'-bromo-4,4-difluorospiro[cyclohexane-1,2'-inden]-1'(3'H)-one	HCID 58197272	—
생성물	6'-Bromospiro[cyclohexane-1,2'-indene]-1',4(3'H)-dione	HCID 58197205	53%

반응 단계

According to a similar synthesis of compound 344, compound 5 (100 mg, 0.26 mmol) was alkylated with compound 2 (159 mg, 1.04 mmol) in the presence of Cs2CO3 (339 mg, 1.04 mmol) to give compound 4 (73 mg, 53%).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08633212B2
출처 데이터셋	uspto-grants-2014_01
ORD ID	ord-f68003fd49a1426c99c19c639bdeb5be
출처 메모	uspto-grants-2014_01