HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 3-(1-Chloroethyl)pyridazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 1-(Pyridazin-3-yl)ethan-1-ol | HCID 15197511 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-(1-Chloroethyl)pyridazine | HCID 58198036 | — |
Reaction Steps
To a solution of 1-(pyridazin-3-yl)ethanol (3) (50 mg, 0.40 mmol) in DCM (1 mL), there was added sulfurous dichloride (0.2 mL). The resulting solution was stirred at room temperature for 3 hrs. Solvent was removed to give 3-(1-chloroethyl)pyridazine (4), which was used for the next step without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08633212B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-63f3345037014146b110c61e3dc454b7 |
| Source note | uspto-grants-2014_01 |