Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,8-Diazabicyclo(5.4.0)undec-7-ene → 1-Chloro-4-[(4-chloro-3-methoxybenzyl)amino]-6-phthalazine carbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| 반응물 | 1,4-Dichlorophthalazine-6-carbonitrile | HCID 10656738 | — |
| 반응물 | 4-Chloro-3-methoxybenzylamine benzylamine hydrochloride | HCID 22744481 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 생성물 | 1-Chloro-4-[(4-chloro-3-methoxybenzyl)amino]-6-phthalazine carbonitrile | HCID 18374614 | — |
반응 단계
4-Chloro-3-methoxybenzylamine benzylamine hydrochloride synthesized according to the method described in WO9518097 and 1,4-dichlorophthalazine-6-carbonitrile were stirred at room temperature in 1-methyl-2-pyrrolidinone in the presence of DBU, whereby 1-chloro-4-[(4-chloro-3-methoxybenzyl)amino]-6-phthalazine carbonitrile was obtained as a less polar product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06699870B2 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-cf4d8edc9a6a4eda9636111a862b0fff |
| 출처 메모 | uspto-grants-2004_03 |